Delivery of the Cre recombinase by a self-deleting lentiviral vector: Efficient gene targeting in vivo

The Cre recombinase (Cre) from bacteriophage P1 is an important tool for genetic engineering in mammalian cells. We constructed lentiviral vectors that efficiently deliver Cre in vitro and in vivo. Surprisingly, we found a significant reduction in proliferation and an accumulation in the G(2)/M phas...

Descripció completa

Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Pfeifer, Alexander, Brandon, Eugene P., Kootstra, Neeltje, Gage, Fred H., Verma, Inder M.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2001
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC58750/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11553794/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.201415498
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!