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Prolyl Hydroxylase PHD3 Activates Oxygen-dependent Protein Aggregation

The HIF prolyl hydroxylases (PHDs/EGLNs) are central regulators of the molecular responses to oxygen availability. One isoform, PHD3, is expressed in response to hypoxia and causes apoptosis in oxygenated conditions in neural cells. Here we show that PHD3 forms subcellular aggregates in an oxygen-de...

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Main Authors: Rantanen, Krista, Pursiheimo, Juha, Högel, Heidi, Himanen, Virpi, Metzen, Eric, Jaakkola, Panu M.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366864/
https://ncbi.nlm.nih.gov/pubmed/18337469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-11-1124
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