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Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma
Most clear cell renal cell carcinomas (ccRCCs) have inactivation of the von Hippel–Lindau tumor suppressor protein (pVHL), resulting in the accumulation of hypoxia-inducible factor α-subunits (HIF-α) and their downstream targets. HIF-2α expression is particularly high in ccRCC and is associated with...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Biol Chem |
|---|---|
| Prif Awduron: | , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Society for Biochemistry and Molecular Biology
2019
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6416423/ https://ncbi.nlm.nih.gov/pubmed/30617181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004902 |
| Tagiau: |
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