HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma

BACKGROUND: A key feature of clear cell renal cell carcinoma (ccRCC) is the inactivation of the von Hippel-Lindau tumour suppressor protein (pVHL) that leads to the activation of hypoxia-inducible factor (HIF) pathway also in well-oxygenated conditions. Important regulator of HIF-α, prolyl hydroxyla...

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Detalles Bibliográficos
Publicado en:Cancer Metab
Main Authors: Miikkulainen, Petra, Högel, Heidi, Rantanen, Krista, Suomi, Tomi, Kouvonen, Petri, Elo, Laura L., Jaakkola, Panu M.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496173/
https://ncbi.nlm.nih.gov/pubmed/28680592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-017-0167-y
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