Design, Synthesis, and Biological Evaluation of Novel Bifunctional C-Terminal-Modified Peptides for δ/μ Opioid Receptor Agonists and Neurokinin-1 Receptor Antagonists

A series of bifunctional peptides that act as agonists for δ and μ opioid receptors with δ selectivity and as antagonist for neurokinin-1 (NK1) receptors were designed and synthesized for potential application as analgesics in various pain states. The peptides were characterized using radioligand bi...

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Autores principales: Yamamoto, Takashi, Nair, Padma, Davis, Peg, Ma, Shou-wu, Navratilova, Edita, Moye, Sharif, Tumati, Suneeta, Lai, Josephine, Vanderah, Todd W., Yamamura, Henry I., Porreca, Frank, Hruby, Victor J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365895/
https://ncbi.nlm.nih.gov/pubmed/17516639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061369n
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