Safety and Immunogenicity of a Gag-Pol Candidate HIV-1 DNA Vaccine Administered by a Needle-Free Device in HIV-1–Seronegative Subjects

OBJECTIVE: To evaluate the safety and immunogenicity of a candidate HIV DNA vaccine administered using a needle-free device. DESIGN: In this phase 1, dose escalation, double-blind, placebo-controlled clinical trial, 21 healthy adults were randomized to receive placebo or 0.5, 1.5, or 4 mg of a singl...

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Hauptverfasser: Tavel, Jorge A., Martin, Julie E., Kelly, Grace G., Enama, Mary E., Shen, Jean M., Gomez, Phillip L., Andrews, Charla A., Koup, Richard A., Bailer, Robert T., Stein, Judy A., Roederer, Mario, Nabel, Gary J., Graham, Barney S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365751/
https://ncbi.nlm.nih.gov/pubmed/17325604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e3180417cb6
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