Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses

BACKGROUND: Induction of HIV-1-specific T-cell responses relevant to diverse subtypes is a major goal of HIV vaccine development. Prime-boost regimens using heterologous gene-based vaccine vectors have induced potent, polyfunctional T cell responses in preclinical studies. METHODS: The first opportu...

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Detalhes bibliográficos
Main Authors: Koup, Richard A., Roederer, Mario, Lamoreaux, Laurie, Fischer, Jennifer, Novik, Laura, Nason, Martha C., Larkin, Brenda D., Enama, Mary E., Ledgerwood, Julie E., Bailer, Robert T., Mascola, John R., Nabel, Gary J., Graham, Barney S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814848/
https://ncbi.nlm.nih.gov/pubmed/20126394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009015
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