Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses

BACKGROUND: Induction of HIV-1-specific T-cell responses relevant to diverse subtypes is a major goal of HIV vaccine development. Prime-boost regimens using heterologous gene-based vaccine vectors have induced potent, polyfunctional T cell responses in preclinical studies. METHODS: The first opportu...

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Main Authors: Koup, Richard A., Roederer, Mario, Lamoreaux, Laurie, Fischer, Jennifer, Novik, Laura, Nason, Martha C., Larkin, Brenda D., Enama, Mary E., Ledgerwood, Julie E., Bailer, Robert T., Mascola, John R., Nabel, Gary J., Graham, Barney S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2010
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814848/
https://ncbi.nlm.nih.gov/pubmed/20126394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009015
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