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Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses

BACKGROUND: Induction of HIV-1-specific T-cell responses relevant to diverse subtypes is a major goal of HIV vaccine development. Prime-boost regimens using heterologous gene-based vaccine vectors have induced potent, polyfunctional T cell responses in preclinical studies. METHODS: The first opportu...

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Главные авторы: Koup, Richard A., Roederer, Mario, Lamoreaux, Laurie, Fischer, Jennifer, Novik, Laura, Nason, Martha C., Larkin, Brenda D., Enama, Mary E., Ledgerwood, Julie E., Bailer, Robert T., Mascola, John R., Nabel, Gary J., Graham, Barney S.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814848/
https://ncbi.nlm.nih.gov/pubmed/20126394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009015
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