Homologous Boosting with Adenoviral Serotype 5 HIV Vaccine (rAd5) Vector Can Boost Antibody Responses despite Preexisting Vector-Specific Immunity in a Randomized Phase I Clinical Trial

BACKGROUND: Needle-free delivery improves the immunogenicity of DNA vaccines but is also associated with more local reactogenicity. Here we report the first comparison of Biojector and needle administration of a candidate rAd5 HIV vaccine. METHODS: Thirty-one adults, 18–55 years, 20 naive and 11 pri...

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Main Authors: Sarwar, Uzma N., Novik, Laura, Enama, Mary E., Plummer, Sarah A., Koup, Richard A., Nason, Martha C., Bailer, Robert T., McDermott, Adrian B., Roederer, Mario, Mascola, John R., Ledgerwood, Julie E., Graham, Barney S.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4179264/
https://ncbi.nlm.nih.gov/pubmed/25264782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106240
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