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Phase 1 Safety and Immunogenicity Evaluation of a Multiclade HIV-1 Candidate Vaccine Delivered by a Replication-Defective Recombinant Adenovirus Vector

BACKGROUND: The development of an effective human immunodeficiency virus (HIV) vaccine is a high global priority. Here, we report the safety, tolerability, and immunogenicity of a replication-defective recombinant adenovirus serotype 5 (rAd5) vector HIV-1 candidate vaccine. METHODS: The vaccine is a...

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Detalhes bibliográficos
Main Authors: Catanzaro, Andrew T., Koup, Richard A., Roederer, Mario, Bailer, Robert T., Enama, Mary E., Moodie, Zoe, Gu, Lin, Martin, Julie E., Novik, Laura, Chakrabarti, Bimal K., Butman, Bryan T., Gall, Jason G. D., King, C. Richter, Andrews, Charla A., Sheets, Rbecca, Gomez, Phillip L., Mascola, John R., Nabel, Gary J., Graham, Barney S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2428071/
https://ncbi.nlm.nih.gov/pubmed/17109335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/509258
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