Phase 1 Safety and Immunogenicity Evaluation of a Multiclade HIV-1 Candidate Vaccine Delivered by a Replication-Defective Recombinant Adenovirus Vector

BACKGROUND: The development of an effective human immunodeficiency virus (HIV) vaccine is a high global priority. Here, we report the safety, tolerability, and immunogenicity of a replication-defective recombinant adenovirus serotype 5 (rAd5) vector HIV-1 candidate vaccine. METHODS: The vaccine is a...

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Main Authors: Catanzaro, Andrew T., Koup, Richard A., Roederer, Mario, Bailer, Robert T., Enama, Mary E., Moodie, Zoe, Gu, Lin, Martin, Julie E., Novik, Laura, Chakrabarti, Bimal K., Butman, Bryan T., Gall, Jason G. D., King, C. Richter, Andrews, Charla A., Sheets, Rbecca, Gomez, Phillip L., Mascola, John R., Nabel, Gary J., Graham, Barney S.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2428071/
https://ncbi.nlm.nih.gov/pubmed/17109335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/509258
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