Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy

Activation of PKA by cAMP agonists, such as 8-Cl-cAMP activation, selectively causes rapid apoptosis in v-abl transformed fibroblasts by inhibiting the Raf-1 kinase. Here we investigated whether 8-Cl-cAMP is useful for the treatment of chronic myelogenous leukaemia (CML), which is hallmarked by the...

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Detalhes bibliográficos
Main Authors: Weissinger, E M, Oettrich, K, Evans, C, Genieser, H-G, Schwede, F, Dangers, M, Dammann, E, Kolb, H-J, Mischak, H, Ganser, A, Kolch, W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364761/
https://ncbi.nlm.nih.gov/pubmed/15188002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601909
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