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Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy
Activation of PKA by cAMP agonists, such as 8-Cl-cAMP activation, selectively causes rapid apoptosis in v-abl transformed fibroblasts by inhibiting the Raf-1 kinase. Here we investigated whether 8-Cl-cAMP is useful for the treatment of chronic myelogenous leukaemia (CML), which is hallmarked by the...
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| Główni autorzy: | , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2004
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2364761/ https://ncbi.nlm.nih.gov/pubmed/15188002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601909 |
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