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The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition
Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized to dTTP for DNA synthesis. Loss of viability following TS inhibition occurs as a consequence of depleted dTTP pools and at least in some cell lines, accumulation of dUTP...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2364072/ https://ncbi.nlm.nih.gov/pubmed/11487279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1921 |
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