The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition

Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized to dTTP for DNA synthesis. Loss of viability following TS inhibition occurs as a consequence of depleted dTTP pools and at least in some cell lines, accumulation of dUTP...

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Hlavní autoři: Webley, S D, Welsh, S J, Jackman, A L, Aherne, G W
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2001
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364072/
https://ncbi.nlm.nih.gov/pubmed/11487279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1921
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