The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition

Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized to dTTP for DNA synthesis. Loss of viability following TS inhibition occurs as a consequence of depleted dTTP pools and at least in some cell lines, accumulation of dUTP...

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Detaylı Bibliyografya
Asıl Yazarlar: Webley, S D, Welsh, S J, Jackman, A L, Aherne, G W
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2001
Konular:
Regular Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364072/
https://ncbi.nlm.nih.gov/pubmed/11487279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1921
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