Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α(1)-acid glycoprotein binding

Dipyridamole has been shown to enhance the in vitro activity of antimetabolite anticancer drugs through the inhibition of nucleoside transport. However, the clinical potential of dipyridamole has not been realized because of the avid binding of the drug to the plasma protein α(1)-acid glycoprotein (...

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Detalhes bibliográficos
Main Authors: Curtin, N J, Bowman, K J, Turner, R N, Huang, B, Loughlin, P J, Calvert, A H, Golding, B T, Griffin, R J, Newell, D R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363125/
https://ncbi.nlm.nih.gov/pubmed/10468290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690591
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