Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors

One of the resistance mechanisms to folate‐based thymidylate synthase (TS) inhibitors is the increase in TS activity in tumor cells. Human B lymphoblastoid cell line (W1L2) was made resistant to a lipophilic non‐polyglutamatable TS inhibitor (ZM249148), and the subline (W1L2:R179) showed a 20‐fold i...

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Dades bibliogràfiques
Publicat a:Jpn J Cancer Res
Autors principals: Kobayashi, Hiroyuki, Takemura, Yuzuru, Miyachi, Hayato, Skelton, Lorraine, Jackman, Ann L.
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 1995
Matèries:
Rapid Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920622/
https://ncbi.nlm.nih.gov/pubmed/8567390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb03014.x
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