Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors

One of the resistance mechanisms to folate‐based thymidylate synthase (TS) inhibitors is the increase in TS activity in tumor cells. Human B lymphoblastoid cell line (W1L2) was made resistant to a lipophilic non‐polyglutamatable TS inhibitor (ZM249148), and the subline (W1L2:R179) showed a 20‐fold i...

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Bibliografski detalji
Izdano u:Jpn J Cancer Res
Glavni autori: Kobayashi, Hiroyuki, Takemura, Yuzuru, Miyachi, Hayato, Skelton, Lorraine, Jackman, Ann L.
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 1995
Teme:
Rapid Communication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920622/
https://ncbi.nlm.nih.gov/pubmed/8567390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb03014.x
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