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Cytotoxicity of Trimetrexate against Antifolate‐resistant Human T‐Cell Leukemia Cell Lines Developed in Oxidized or Reduced Folate

Cytotoxicity of trimetrexate (TMQ), a lipophilic dihydrofolate reductase inhibitor, was examined in antifolate‐resistant human T‐cell leukemia cell lines developed in oxidized or reduced folate. An approximately 60‐fold methotrexate (MTX)‐resistant subline was developed in oxidized folate (pter‐oylg...

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Библиографические подробности
Опубликовано в: :Jpn J Cancer Res
Главные авторы: Miyachi, Hayato, Takemura, Yuzuru, Kobayashi, Hiroyuki, Ando, Yasuhiko
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 1997
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921512/
https://ncbi.nlm.nih.gov/pubmed/9369939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00467.x
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