Cytotoxicity of Trimetrexate against Antifolate‐resistant Human T‐Cell Leukemia Cell Lines Developed in Oxidized or Reduced Folate

Cytotoxicity of trimetrexate (TMQ), a lipophilic dihydrofolate reductase inhibitor, was examined in antifolate‐resistant human T‐cell leukemia cell lines developed in oxidized or reduced folate. An approximately 60‐fold methotrexate (MTX)‐resistant subline was developed in oxidized folate (pter‐oylg...

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Publicado en:Jpn J Cancer Res
Autores principales: Miyachi, Hayato, Takemura, Yuzuru, Kobayashi, Hiroyuki, Ando, Yasuhiko
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 1997
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921512/
https://ncbi.nlm.nih.gov/pubmed/9369939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00467.x
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