Cytotoxicity of Trimetrexate against Antifolate‐resistant Human T‐Cell Leukemia Cell Lines Developed in Oxidized or Reduced Folate

Cytotoxicity of trimetrexate (TMQ), a lipophilic dihydrofolate reductase inhibitor, was examined in antifolate‐resistant human T‐cell leukemia cell lines developed in oxidized or reduced folate. An approximately 60‐fold methotrexate (MTX)‐resistant subline was developed in oxidized folate (pter‐oylg...

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Foilsithe in:Jpn J Cancer Res
Main Authors: Miyachi, Hayato, Takemura, Yuzuru, Kobayashi, Hiroyuki, Ando, Yasuhiko
Formáid: Artigo
Teanga:Inglês
Foilsithe: Blackwell Publishing Ltd 1997
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921512/
https://ncbi.nlm.nih.gov/pubmed/9369939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00467.x
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