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Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate.
Trimetrexate, a highly lipid-soluble quinazoline antifolate now undergoing trials as an anticancer agent, was found to be a potent inhibitor of the dihydrofolate reductase (DHFR) isolated from Toxoplasma gondii. The concentration required for 50% inhibition of protozoal DHFR was 1.4 nM. As an inhibi...
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主要な著者: | , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
1987
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC424107/ https://ncbi.nlm.nih.gov/pubmed/2948969 |
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