Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate.

Trimetrexate, a highly lipid-soluble quinazoline antifolate now undergoing trials as an anticancer agent, was found to be a potent inhibitor of the dihydrofolate reductase (DHFR) isolated from Toxoplasma gondii. The concentration required for 50% inhibition of protozoal DHFR was 1.4 nM. As an inhibi...

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Hauptverfasser: Allegra, C J, Kovacs, J A, Drake, J C, Swan, J C, Chabner, B A, Masur, H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1987
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC424107/
https://ncbi.nlm.nih.gov/pubmed/2948969
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