Lipophilic Antifolate Trimetrexate Is a Potent Inhibitor of Trypanosoma cruzi: Prospect for Chemotherapy of Chagas' Disease

Trypanosoma cruzi, a protozoan parasite, is the causative agent for Chagas' disease, which poses serious public health problem in Latin America. The two drugs available for the treatment of this disease are effective only against recent infections and are toxic. Dihydrofolate reductase (DHFR) h...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Senkovich, Olga, Bhatia, Vandanajay, Garg, Nisha, Chattopadhyay, Debasish
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2005
Gaiak:
Mechanisms of Action: Physiological Effects
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196212/
https://ncbi.nlm.nih.gov/pubmed/16048931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3234-3238.2005
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