Hypermethylation of the 5′ CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis

The Testisin gene (PRSS21) encodes a glycosylphosphatidylinositol (GPI)-linked serine protease that exhibits testis tissue-specific expression. Loss of Testisin has been implicated in testicular tumorigenesis, but its role in testis biology and tumorigenesis is not known. Here we have investigated t...

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Detalhes bibliográficos
Main Authors: Manton, K J, Douglas, M L, Netzel-Arnett, S, Fitzpatrick, D R, Nicol, D L, Boyd, A W, Clements, J A, Antalis, T M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361880/
https://ncbi.nlm.nih.gov/pubmed/15685234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602373
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