Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1®

Cellular expression of ATP-binding cassette (ABC) transport proteins, such as P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), or ABCG2, is known to confer a drug-resistant phenotype. Thus, the development of effective transporter inhibitors could be of value to cancer treatment...

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Главные авторы: Robey, Robert W., Shukla, Suneet, Finley, Elizabeth M., Oldham, Robert K., Barnett, Daryl, Ambudkar, Suresh V., Fojo, Tito, Bates, Susan E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346578/
https://ncbi.nlm.nih.gov/pubmed/18234154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.12.001
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