A Pharmacodynamic Study of the P-glycoprotein Antagonist CBT-1® in Combination With Paclitaxel in Solid Tumors

BACKGROUND: This pharmacodynamic trial evaluated the effect of CBT-1® on efflux by the ATP binding cassette (ABC) multidrug transporter P-glycoprotein (Pgp/MDR1/ABCB1) in normal human cells and tissues. CBT-1® is an orally administered bisbenzylisoquinoline Pgp inhibitor being evaluated clinically....

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Detalhes bibliográficos
Main Authors: Kelly, Ronan J., Robey, Robert W., Chen, Clara C., Draper, Deborah, Luchenko, Victoria, Barnett, Daryl, Oldham, Robert K., Caluag, Zinnah, Frye, A. Robin, Steinberg, Seth M., Fojo, Tito, Bates, Susan E.
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2012
Assuntos:
Clinical Trial Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336838/
https://ncbi.nlm.nih.gov/pubmed/22416063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0080
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