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Grafting a new metal ligand in the cocatalytic site of B. cereus metallo-β-lactamase: Structural flexibility without loss of activity

Metallo-β-lactamases are zinc enzymes able to hydrolyze the four-membered ring of β-lactam antibiotics, representing one of the latest generations of β-lactamases. These enzymes belong to the zinc metallo-hydrolase family of the β-lactamase fold. Enzymes belonging to this family have a bimetallic ac...

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Bibliografske podrobnosti
Main Authors: Rasia, Rodolfo M., Ceolín, Marcelo, Vila, Alejandro J.
Format: Artigo
Jezik:Inglês
Izdano: Wiley-Blackwell 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323933/
https://ncbi.nlm.nih.gov/pubmed/12824499
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