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Grafting a new metal ligand in the cocatalytic site of B. cereus metallo-β-lactamase: Structural flexibility without loss of activity
Metallo-β-lactamases are zinc enzymes able to hydrolyze the four-membered ring of β-lactam antibiotics, representing one of the latest generations of β-lactamases. These enzymes belong to the zinc metallo-hydrolase family of the β-lactamase fold. Enzymes belonging to this family have a bimetallic ac...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Wiley-Blackwell
2003
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323933/ https://ncbi.nlm.nih.gov/pubmed/12824499 |
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