Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.

The Janus protein tyrosine kinases (Jaks) play critical roles in transducing growth and differentiation signals emanating from ligand-activated cytokine receptor complexes. The activation of the Jaks is hypothesized to occur as a consequence of auto- or transphosphorylation on tyrosine residues asso...

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Bibliographic Details

Published in:	Mol Cell Biol
Main Authors:	Feng, J, Witthuhn, B A, Matsuda, T, Kohlhuber, F, Kerr, I M, Ihle, J N
Format:	Artigo
Language:	Inglês
Published:	Taylor & Francis 1997
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232098/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9111318/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.5.2497
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