Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.

The Janus protein tyrosine kinases (Jaks) play critical roles in transducing growth and differentiation signals emanating from ligand-activated cytokine receptor complexes. The activation of the Jaks is hypothesized to occur as a consequence of auto- or transphosphorylation on tyrosine residues asso...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Feng, J, Witthuhn, B A, Matsuda, T, Kohlhuber, F, Kerr, I M, Ihle, J N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232098/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9111318/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.5.2497
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