Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.

The Janus protein tyrosine kinases (Jaks) play critical roles in transducing growth and differentiation signals emanating from ligand-activated cytokine receptor complexes. The activation of the Jaks is hypothesized to occur as a consequence of auto- or transphosphorylation on tyrosine residues asso...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Feng, J, Witthuhn, B A, Matsuda, T, Kohlhuber, F, Kerr, I M, Ihle, J N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232098/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9111318/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.5.2497
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