Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers

AIMS: To assess the potential of known CYP3A4 inducers, with and without CYP3A4 inhibitors, to alter the pharmacokinetic profile of maraviroc. METHODS: Two separate, open, randomized, placebo-controlled studies were conducted in healthy subjects. Study 1 was a 28-day parallel-group study with three...

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Autores principales: Abel, Samantha, Jenkins, Timothy M, Whitlock, Lyndsey A, Ridgway, Caroline E, Muirhead, Gary J
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2008
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2311410/
https://ncbi.nlm.nih.gov/pubmed/18333864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03134.x
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