Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers

AIMS: To evaluate the influence of cytochrome P450 (CYP) 3A4 inhibitors on the clinical pharmacokinetics of maraviroc, a novel CCR5 antagonist. METHODS: Four open-label, randomized, placebo-controlled studies were conducted in healthy subjects to assess the effect of separate and distinct combinatio...

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Main Authors: Abel, Samantha, Russell, Deborah, Taylor-Worth, Richard J, Ridgway, Caroline E, Muirhead, Gary J
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2008
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2311406/
https://ncbi.nlm.nih.gov/pubmed/18333863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03133.x
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