A refractory phase in cyclic AMP-responsive transcription requires down regulation of protein kinase A.
Cyclic AMP (cAMP) stimulates the expression of numerous genes through the protein kinase A (PK-A)-mediated phosphorylation of the nuclear factor CREB at Ser-133 (G. A. Gonzalez and M. R. Montminy, Cell 59:675-680, 1989). Like other signal transduction pathways, cAMP induces gene expression with burs...
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| Veröffentlicht in: | Mol Cell Biol |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
1995
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230407/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7862172/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.3.1826 |
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