Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways

Summary: The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and the cAMP-regulated transcription co-activators 1–3 (CRTC1–3). Differentiation is dysregulated in melanomas, although the contributions of CRTC proteins is unclear. We report a selective differentiation impairm...

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Principais autores:	Jelena Ostojić, Young-Sil Yoon, Tim Sonntag, Billy Nguyen, Joan M. Vaughan, Maxim Shokhirev, Marc Montminy
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2021-05-01
Series:	Cell Reports
Assuntos:	cAMP CREB CRTC3 OCA2 melanosome phospho-diesterase
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211124721004757
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