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Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways

Summary: The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and the cAMP-regulated transcription co-activators 1–3 (CRTC1–3). Differentiation is dysregulated in melanomas, although the contributions of CRTC proteins is unclear. We report a selective differentiation impairm...

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Principais autores: Jelena Ostojić, Young-Sil Yoon, Tim Sonntag, Billy Nguyen, Joan M. Vaughan, Maxim Shokhirev, Marc Montminy
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-05-01
Serier:Cell Reports
Fag:
cAMP
CREB
CRTC3
OCA2
melanosome
phospho-diesterase
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124721004757
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