Resistance of Human Cytomegalovirus to the Benzimidazole l-Ribonucleoside Maribavir Maps to UL27

1-(β-d-Ribofuranosyl)-2,5,6-trichlorobenzimidazole (TCRB) and its 2-bromo analog, BDCRB, are potent and selective inhibitors of human cytomegalovirus (HCMV) DNA processing and packaging. Since they are readily metabolized in vivo, analogs were synthesized to improve biostability. One of these, 1-(β-...

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Detalles Bibliográficos
Autores principales: Komazin, Gloria, Ptak, Roger G., Emmer, Brian T., Townsend, Leroy B., Drach, John C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC229258/
https://ncbi.nlm.nih.gov/pubmed/14557635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.21.11499-11506.2003
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