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Resistance of Human Cytomegalovirus to the Benzimidazole l-Ribonucleoside Maribavir Maps to UL27

1-(β-d-Ribofuranosyl)-2,5,6-trichlorobenzimidazole (TCRB) and its 2-bromo analog, BDCRB, are potent and selective inhibitors of human cytomegalovirus (HCMV) DNA processing and packaging. Since they are readily metabolized in vivo, analogs were synthesized to improve biostability. One of these, 1-(β-...

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書誌詳細
主要な著者: Komazin, Gloria, Ptak, Roger G., Emmer, Brian T., Townsend, Leroy B., Drach, John C.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC229258/
https://ncbi.nlm.nih.gov/pubmed/14557635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.21.11499-11506.2003
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