Resistance of Human Cytomegalovirus to the Benzimidazole l-Ribonucleoside Maribavir Maps to UL27

1-(β-d-Ribofuranosyl)-2,5,6-trichlorobenzimidazole (TCRB) and its 2-bromo analog, BDCRB, are potent and selective inhibitors of human cytomegalovirus (HCMV) DNA processing and packaging. Since they are readily metabolized in vivo, analogs were synthesized to improve biostability. One of these, 1-(β-...

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Main Authors: Komazin, Gloria, Ptak, Roger G., Emmer, Brian T., Townsend, Leroy B., Drach, John C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2003
Ábhair:
Vaccines and Antiviral Agents
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC229258/
https://ncbi.nlm.nih.gov/pubmed/14557635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.21.11499-11506.2003
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