Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency

Supravalvular aortic stenosis is an autosomal-dominant disease of elastin (Eln) insufficiency caused by loss-of-function mutations or gene deletion. Recently, we have modeled this disease in mice (Eln(+/–)) and found that Eln haploinsufficiency results in unexpected changes in cardiovascular hemodyn...

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Main Authors: Faury, Gilles, Pezet, Mylène, Knutsen, Russell H., Boyle, Walter A., Heximer, Scott P., McLean, Sean E., Minkes, Robert K., Blumer, Kendall J., Kovacs, Attila, Kelly, Daniel P., Li, Dean Y., Starcher, Barry, Mecham, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2003
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC228452/
https://ncbi.nlm.nih.gov/pubmed/14597767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200319028
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