Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency

Supravalvular aortic stenosis is an autosomal-dominant disease of elastin (Eln) insufficiency caused by loss-of-function mutations or gene deletion. Recently, we have modeled this disease in mice (Eln(+/–)) and found that Eln haploinsufficiency results in unexpected changes in cardiovascular hemodyn...

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Detalhes bibliográficos
Main Authors: Faury, Gilles, Pezet, Mylène, Knutsen, Russell H., Boyle, Walter A., Heximer, Scott P., McLean, Sean E., Minkes, Robert K., Blumer, Kendall J., Kovacs, Attila, Kelly, Daniel P., Li, Dean Y., Starcher, Barry, Mecham, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC228452/
https://ncbi.nlm.nih.gov/pubmed/14597767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200319028
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