Elastin Haploinsufficiency Induces Alternative Aging Processes in the Aorta

Elastin, the main component of elastic fibers, is synthesized only in early life and provides the blood vessels with their elastic properties. With aging, elastin is progressively degraded, leading to arterial enlargement, stiffening, and dysfunction. Also, elastin is a key regulator of vascular smo...

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Main Authors: Pezet, Mylène, Jacob, Marie-Paule, Escoubet, Brigitte, Gheduzzi, Dealba, Tillet, Emmanuelle, Perret, Pascale, Huber, Philippe, Quaglino, Daniela, Vranckx, Roger, Li, Dean Y., Starcher, Barry, Boyle, Walter A., Mecham, Robert P., Faury, Gilles
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729436/
https://ncbi.nlm.nih.gov/pubmed/18173368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/rej.2007.0587
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