Elastin Haploinsufficiency Induces Alternative Aging Processes in the Aorta

Elastin, the main component of elastic fibers, is synthesized only in early life and provides the blood vessels with their elastic properties. With aging, elastin is progressively degraded, leading to arterial enlargement, stiffening, and dysfunction. Also, elastin is a key regulator of vascular smo...

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Detalhes bibliográficos
Main Authors: Pezet, Mylène, Jacob, Marie-Paule, Escoubet, Brigitte, Gheduzzi, Dealba, Tillet, Emmanuelle, Perret, Pascale, Huber, Philippe, Quaglino, Daniela, Vranckx, Roger, Li, Dean Y., Starcher, Barry, Boyle, Walter A., Mecham, Robert P., Faury, Gilles
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729436/
https://ncbi.nlm.nih.gov/pubmed/18173368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/rej.2007.0587
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