Elastin Haploinsufficiency Induces Alternative Aging Processes in the Aorta

Elastin, the main component of elastic fibers, is synthesized only in early life and provides the blood vessels with their elastic properties. With aging, elastin is progressively degraded, leading to arterial enlargement, stiffening, and dysfunction. Also, elastin is a key regulator of vascular smo...

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Autors principals: Pezet, Mylène, Jacob, Marie-Paule, Escoubet, Brigitte, Gheduzzi, Dealba, Tillet, Emmanuelle, Perret, Pascale, Huber, Philippe, Quaglino, Daniela, Vranckx, Roger, Li, Dean Y., Starcher, Barry, Boyle, Walter A., Mecham, Robert P., Faury, Gilles
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729436/
https://ncbi.nlm.nih.gov/pubmed/18173368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/rej.2007.0587
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