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Inhibition of microRNA 29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels
SUMMARY: OBJECTIVE: To determine if antagonizing miR 29 enhances elastin (ELN) levels in cells and tissues lacking ELN. Methods and RESULTS: miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased EL...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3288647/ https://ncbi.nlm.nih.gov/pubmed/22095981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.238113 |
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