Inhibition of microRNA 29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels

SUMMARY: OBJECTIVE: To determine if antagonizing miR 29 enhances elastin (ELN) levels in cells and tissues lacking ELN. Methods and RESULTS: miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased EL...

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Hauptverfasser: Zhang, Pei, Huang, Angela, Ferruzzi, Jacopo, Mecham, Robert P., Starcher, Barry C., Tellides, George, Humphrey, Jay D., Giordano, Frank J., Niklason, Laura E., Sessa, William C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288647/
https://ncbi.nlm.nih.gov/pubmed/22095981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.238113
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