Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy

Thioredoxin 1 (Trx1) has redox-sensitive cysteine residues and acts as an antioxidant in cells. However, the extent of Trx1 contribution to overall antioxidant mechanisms is unknown in any organs. We generated transgenic mice with cardiac-specific overexpression of a dominant negative (DN) mutant (C...

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Hauptverfasser: Yamamoto, Mitsutaka, Yang, Guiping, Hong, Chull, Liu, Jing, Holle, Eric, Yu, Xianzhong, Wagner, Thomas, Vatner, Stephen F., Sadoshima, Junichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC228400/
https://ncbi.nlm.nih.gov/pubmed/14597765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317700
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