The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy

Mitogen-activated protein kinase kinase kinase (MEKK1) mediates activation of c-Jun NH(2)-terminal kinase (JNK). Although previous studies using cultured cardiac myocytes have suggested that the MEKK1-JNK pathway plays a key role in hypertrophy and apoptosis, its effects in cardiac hypertrophy and a...

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Bibliographische Detailangaben
Hauptverfasser: Sadoshima, Junichi, Montagne, Olivier, Wang, Qian, Yang, Guiping, Warden, Jill, Liu, Jing, Takagi, Gen, Karoor, Vijaya, Hong, Chull, Johnson, Gary L., Vatner, Dorothy E., Vatner, Stephen F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2002
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC151048/
https://ncbi.nlm.nih.gov/pubmed/12122119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14938
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