Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload

The sympathetic nervous system is designed to respond to stress. Adenylyl cyclase (AC) is the keystone of sympathetic transmission, yet its role in response to acute overload in the heart or in the pathogenesis of heart failure is controversial. We examined the effects of pressure overload, induced...

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Bibliographic Details
Main Authors: Okumura, Satoshi, Takagi, Gen, Kawabe, Jun-ichi, Yang, Guiping, Lee, Ming-Chih, Hong, Chull, Liu, Jing, Vatner, Dorothy E., Sadoshima, Junichi, Vatner, Stephen F., Ishikawa, Yoshihiro
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC187910/
https://ncbi.nlm.nih.gov/pubmed/12904575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1733772100
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