Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload

The sympathetic nervous system is designed to respond to stress. Adenylyl cyclase (AC) is the keystone of sympathetic transmission, yet its role in response to acute overload in the heart or in the pathogenesis of heart failure is controversial. We examined the effects of pressure overload, induced...

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Detalhes bibliográficos
Main Authors: Okumura, Satoshi, Takagi, Gen, Kawabe, Jun-ichi, Yang, Guiping, Lee, Ming-Chih, Hong, Chull, Liu, Jing, Vatner, Dorothy E., Sadoshima, Junichi, Vatner, Stephen F., Ishikawa, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC187910/
https://ncbi.nlm.nih.gov/pubmed/12904575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1733772100
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