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Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
Thioredoxin 1 (Trx1) has redox-sensitive cysteine residues and acts as an antioxidant in cells. However, the extent of Trx1 contribution to overall antioxidant mechanisms is unknown in any organs. We generated transgenic mice with cardiac-specific overexpression of a dominant negative (DN) mutant (C...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC228400/ https://ncbi.nlm.nih.gov/pubmed/14597765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317700 |
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